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KMID : 0363020050350040851
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Journal of Korean Academy of Periodontology
2005 Volume.35 No. 4 p.851 ~ p.861
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Osteoblast adhesion and differentiation on magnesium titanate surface
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최승민
이재관/고성희/엄흥식/장범석
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Abstract
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The nature of the implant surface can directly influence cellular response, ultimately
affecting the rate and quality of new bone tissue formation. The aim of this in vitro study was
to investigate if human osteoblast-like cells, Saos-2, would respond differently when plated on
disks of magnesium titanate and machined titanium.
Magnesium titanate disks were prepared using Micro Arc Oxidation(MAO) methods. Control
samples were machined commercially pure titanium disks. The cell adhesion, proliferation and
differentiation were evaluated by measuring cell number, and alkaline phosphatase(ALPase)
activity at 1 day and 6 day after plating on the titanium disks. Measurement of cell number and
ALPase activity in Saos-2 cells at 1 day did not demonstrate any difference between machined
titanium and magnesium titanate. When compared to machined titanium disks, the number of
cells was reduced on the magnesium titanate disks at 6 day, while ALPase activity was more
pronounced on the magnesium titanate.
Enhanced differentiation of cells grown on magnesium titanate samples was indicated by
decreased cell proliferation and increased ALPase activity.
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KEYWORD
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Magnesium titanate, Osteoblast cell differentiation, Alkaline phosphatase activity
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